Ashwagandha Protects the Neuron Against Brain Dysfunction

By Kyle J. Norton

The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.

Neuroinflammation is a process of the immune system response to harmful pathogens that induced oxidative stress to the brain.

Neuroinflammation is also the inflammation of nervous tissue associated with the immune response in the first phase of infection including infection, traumatic brain injury, toxic metabolites, or autoimmunity.

Neurological disorders are class of diseases associated with the brain, the spinal cord including the nerves that connect them.

Most common diseases of neurological disorders are dementia, including ALS. PD, Alzheimer’s disease, birth defects of the brain and spinal cord, brain injury and tumor.

Back pain associated with the related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.

There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.

Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen on post-stroke patients, difficulty reading and writing and poor cognitive abilities such as patients with dementia.

According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.

Neurodegenerative diseases are the most common forms of low-grade chronic neuroinflammation, including Alzheimer’s disease, vascular dementia, and dementia with Lewy bodies.

Dr. WEI-WEI CHEN, the lead scientist at the Xuzhou Central Hospital in the investigation of inflammatory cytokines and chronic neuroinflammation wrote, “Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia”
And, “These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments.”.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for enhancing brain performance, researchers examined the ashwagandha effects on the neurons.

Epidemiologically, environmental stressors have been found to cause global concerns of the modern society, by rapidly increasing the incidence of a variety of pathological conditions including brain tumors, neurodegenerative & neuropsychiatric disorders.

Ashwagandha used in Indian traditional home medicine showed to process the anti-stress and remedial potential for the treatment of aging and neurodegenerative pathologies, including the environmental toxins.

Furthermore, Ashwagandha extracts and its active principles also exerted the underlying molecular mechanism(s) that inhibits the brain pathologies through the herb nootropic potency.
Moreover, in the examing the Ashwagandha leaf extracts effects, researchers found that the Ashwagandha inhibited neuroblastoma and glioma cells initiation, and reversal of Alzheimer and Parkinson’s pathologies, protection against environmental neurotoxins and enhancement of memory.

Based on the findings, researchers said, “ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program”.

Taken altogether, Ashwagandha may be considered a functional herb that increases body mass and strength in resistance training, pending to the result of larger sample size and multicenter study

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts by Wadhwa R1, Konar A1, Kaul SC. (PubMed)
(2) Role of neuroinflammation in neurodegenerative diseases (Review) by Chen WW1, Zhang X1, Huang WJ. (PubMed)