Cranberry, the Anti-Psychosis Remedy

By Kyle J. Norton

Psychosis is an abnormal condition that causes the inability of the mind to determine what is real and what is not, leading to abnormal behaviors, and emotions.

Most common symptoms of psychosis are false beliefs or delusions and seeing or hearing things that a healthy person does not see or hear.

According to the statistics provided by the US government, in 2017, approximately 46.6 million adults aged 18 or older in the United States are living with mental illness, representing 18.9% of all U.S. adults.

The Mental Health Illness suggested that 3.5% of the American population is experiencing psychosis. 

Most common  psychotic disorders are

* Schizophrenia: is a serious mental disorder that affects how a person thinks, feels, and acts.

* Schizophreniform disorder is considered the acute case of Schizophrenia with symptoms that occur for a time period of at least one month but no more than six months.

* Schizoaffective Disorder: is a condition with symptoms similar to those of schizophrenia, accompanied by additional periodic symptoms of mood (or affective) disorders.

Besides hearing or seeing something that is not real, other common symptoms of psychosis disorder are a constant feeling of being watched, disorganized or bizarre speech or writing, inappropriate or unusual behavior and strange body movements or positioning.

Some patients may also experience symptoms of a change in personal hygiene, appearance and personality, irrational, angry or fearful response to loved ones and inability to sleep or concentrate.

Conventionally, early diagnosis of psychosis can increase the rate of od successful treatment.

Combination of antipsychotic medication and family intervention, cognitive behavioral therapy, supportive psychotherapy and case management, skills training, and education have been found to induce treatment outcome.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia.

 Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of mental disorders associated with illusion, researchers examined the effect of aqueous cranberry extract (ACE) on MK-801-induced psychosis in mice.

The study included selected MK-801-treated mice administered ACE (1 and 2 g/kg, p.o.) for 14 days.



According to tested differentiation of various behavioral parameters and neurochemical estimations such as dopamine (DA), 5-hydroxytryptamine (5-HT), norepinephrine (NE), gamma-aminobutyric acid (GABA), glutamate, and glycine and markers of oxidative stress such as nitrate levels,  psychosis-induced mice exerted a significant elevation of immobility time in forced swim test, locomotor activity, and reduction in time of permanency in rota-rod test, escape latency time in Cook’s pole test.

However, after treatment of ACE, MK-801-induced psychosis exerted a significant alteration in above-mentioned behavioral parameters.

Furthermore, ACE also showed a reversal of a significant increase in DA, 5-HT, and NA levels and a decrease in GABA, glutamate, and glycine levels in the brain associated with improved psychotic function against MK-801- mice.

Moreover, ACE-treated mice showed a substantial reduction in acetylcholinesterase, D-amino acid oxidase enzyme activity, and nitrite levels associated with oxidative stress elevated by the administration of MK-801.

Based on the findings, researchers aid, “Treatment with ACE once for 14 days (1 and 2 g/kg) significantly ameliorated the behavioral symptoms in experimentally induced psychosis by virtue of neuromodulation and decreased oxidative stress”.

Taken altogether, cranberry may be considered a remedy for the treatment of psychosis, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Vaccinium macrocarpon on MK-801-induced psychosis in mice by Shukla D1, Maheshwari RA1, Patel K2, Balaraman R1, Sen AK. (PubMed)