Healthy Food Turmeric Improves the Function of Peripheral Nerves, Neuropathy in Patients with Dejerine-Sottas Disease

By Kyle J. Norton

Dejerine-Sottas disease is an inherited neurological disorder that causes the enlarged or thickened peripheral nerves, leading to muscle weakness.

Most cases of Dejerine-Sottas disease begin suddenly, in population between 10 and 30 years of age.
Beside muscle weakness, patients with the disease also experience symptoms of pain, weakness, numbness, and a tingling, prickling or burning sensation in the legs. 
Conventionally, treatment of Dejerine-Sottas disease is focusing on reducing symptoms and slowing the progression of the disease and improving quality of life.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential compound for the treatment of Charcot-Marie-Tooth disease type 1B caused by mutations in myelin protein zero, researchers examined the effect of turmeric on an animal model.

The study included R98C mice, an authentic model induced the early onset Charcot-Marie-Tooth disease type 1B, in the developing neuropathy.

According to the tested assays, R98C mutant mice were treated with curcumin dissolved in sesame oil or phosphatidylcholine curcumin, starting at 4 days of age showed an increased numbers of large-diameter axons in their sciatic nerve.

The aforementioned compound also demonstrated an increased compound muscle action potential amplitudes and the innervation of neuromuscular junctions without improving the nerve conduction velocity, myelin thickness, G-ratios or myelin period in transmitting electrical impulses. 
Additionally, the protein associated with the onset of neurodegenerative disease X-box binding protein (XBP1) splicing was also decreased by the treatment of curcumin dissolved in sesame oil or phosphatidylcholine curcumin.

Based on the findings, researchers wrote, “these data demonstrate that treatment with curcumin dissolved in sesame oil or phosphatidylcholine curcumin improves the peripheral neuropathy of R98C mice by alleviating endoplasmic reticulum stress, by reducing the activation of unfolded protein response and by promoting Schwann cell differentiation”.


In other words, curcumin protects the nerve cells against the onset of peripheral neuropathy by reducing the nerves damage that carries messages to and from the brain and spinal cord from and to the rest of the body.

Taken altogether, turmeric may be considered supplements for the treatment of neuropathy in patients with Dejerine-Sottas disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice by Patzkó A1, Bai Y, Saporta MA, Katona I, Wu X, Vizzuso D, Feltri ML, Wang S, Dillon LM, Kamholz J, Kirschner D, Sarkar FH, Wrabetz L, Shy ME. (PubMed)