Herbal Turmeric, a Natural Prevention and Treatment of Diabetes

By Kyle J. Norton

Diabetes is a medical condition characterized by insufficient insulins in the bloodstream. or insulins in the bloodstream are not used properly to convert glucose to energy.

Epidemiologically, diabetes is caused either the beta cells in the pancreas died-off or insulin receptors with a function that use insulin to convert glucose to energy clogged-up by fat or cholesterol.

In a healthy individual, after eating, the rise of blood glucose triggers the production of insulin by the pancreas into bloodstream After you eat, your blood sugar (glucose) rises. This rise in glucose triggers your pancreas to release insulin into the bloodstream that travels through the blood to your body’s cells before converting glucose into energy or store it to use later.

In other words, insulin released by the pancreas joints with the Insulin receptors on the outer part of a cell that binds insulin in the blood to convert glucose to energy.

If insulin produced by the pancreas can not bind with the insulin receptors, the levels of glucose in the blood remain high that triggers more release of more insulin by the pancreas, leading to insulin resistance, a hallmark of type 2 diabetes.
Diabetics with long-term untreated hyperglycemia may induce some serious complications
* Gangrene
Gangrene is a condition of the death of tissue in part of the body. 
* Loss of sensation in limbs
According to Dr. Boulton AJ. at the universities of Manchester, neuropathy is silent in up to 50% of patients.
*Amputation
Amputation is a result of nerve damage and poor blood circulation to the foot of that can lead to poor healing of foot-ulceration. 
* Diabetic retinopathy
Diabetic retinopathy is a condition that causes damage to the blood vessels of the light-sensitive tissue at the back of the eye.

* Diabetic gastropathy

Diabetic gastropathy a condition of neuromuscular dysfunctions in the stomach, including abnormalities of gastric contractility, tone, and myoelectrical activity in patients with diabetes(30).
* Oral and dental complications
According to the study by Department of Medicine, MLN Medical College, Allahabad, oral manifestations in DM of which included periodontal disease in 34%, oral candidiasis in 24%, tooth loss in 24%, oral mucosal ulcers in 22%, taste impairment in 20%, xerostomia and salivary gland hypofunction in 14%, dental caries in 24%, and burning mouth sensation in 10% cases.
* Recurrent infections
Women with diabetes have an increased risk of urinary tract infections (UTIs), especially recurrences. Relapses and reinfections were reported in 7.1% and 15.9% of women with diabetes versus 2.0% and 4.1% of women without diabetes.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of diabetes with no side effects researchers investigated the anti-diabetic capacity of Curcuma longa volatile oil in terms of its ability to inhibit glucosidase activities.

According to the tested results, turmeric volatile oils are more effective in the inhibition of glucosidase enzymes compared to those of reference standard drug acarbose.

More precisely, the efficacy of turmeric volatile oils were attributed to the drying of rhizomes in enhancing α-glucosidase (IC₅₀ = 1.32-0.38 μg/ml) and α-amylase (IC₅₀ = 64.7-34.3 μg/ml) inhibitory capacities, particularly in Ar-Turmerone, the major volatile component. 

In order to reveal additional information about the effect of turmeric, researchers investigated the inhibitory property of turmeric as an adjuvant to anti-diabetic therapy.

The human trial including 60 diabetic subjects on metformin therapy randomized into two groups (30 each) either treated with (group I) standard metformin treatment or standard metformin therapy with turmeric (2 g) supplements (group II) for 4 weeks.

According to the experimental results, turmeric supplementation plus metformin-treated type 2 diabetic patient significantly decreased fasting glucose, and HbA1c levels compared to group I.

Futhermore, reduction in lipid peroxidation, MDA, an oxidative stress marker and enhanced total antioxidant status were also found in group II.

Moreover, turmeric also improved the parameters associated with diabetics such as dyslipidemia LDL cholesterol, non HDL cholesterol and LDL/HDL ratio (3.01 ± 0.61, P < 0.01) and reduced inflammatory marker, hsCRP.

Dr. Maithili Karpaga Selvi N, the lead scientist said, “Turmeric supplementation as an adjuvant to T2DM on metformin treatment had a beneficial effect on blood glucose, oxidative stress and inflammation”.

Taken altogether, turmeric used alone or combined with other medicine may be considered supplements for the prevention and treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes by Lekshmi PC1, Arimboor R, Indulekha PS, Menon AN. (PubMed)
(2) Efficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic Patients by Maithili Karpaga Selvi N1, Sridhar MG1, Swaminathan RP2, Sripradha R. (PubMed)
(3) Diabetes – The Complications by Kyle J. Norton