Herbal Turmeric Kills Kidney Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a group of diseases associated with cells growing and multiplying disordered and uncontrollable in the tissue of the specific organ.

Over time, the alternation of the cell DNA on the surface on the inner lining tissue may become progressively worse by penetrating into deeper layers of the infected organs.
At the advanced stage, cells of most invasive tumors can spread to other organs in the body via lymph or blood.

The kidney is an essential organ of our body, that not only plays a critical role in the urinary system, but also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin.

In the urinary system, kidney filters blood with billions of glomeruli by separating the cells of blood from plasma. 
As the plasma passing into the tubules, some necessary substances are reabsorbed back into the blood, while others waste, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.

Renal cell carcinoma is the most common type of kidney cancer caused by malignant cells of the lining of the tubules in the kidney. Renal cell carcinoma tends first to spread to the lung, but it may also spread to lymph nodes and other organs as well.
Because of less nervous in the kidney and location, patients in the early stage of renal cell carcinoma are asymptomatic. In other words, kidney tumor can grow without causing any pain and discomfort. Most common symptoms of kidney cancer are
* Abdominal pain that is dull and constant lasting for hours.
*Back pain that is dull and constant lasting for hours.
* Blood in the urine is a result of break off of the tumor in the tubules.
* Unintentional weight loss
Any intentional weight loss of over 10% is one of the most common symptoms of cancer.
*  Flank pain is a sensation of discomfort, distress, or agony in around the back and side of the abdomen.
* Swelling and enlargement of the abdomen happens to approximate 15% of all cases of renal cell carcinoma. 
*Anemia
If cancer has affected the function of erythropoietin in the production of hemoglobin.
* Varicocele enlargement is a result of the blockage of the left (right) testicular vein by tumor invasion of the left (right) renal vein.
*Hypertension is a result of secretion of renin by the tumor.
If you experience some of the aforementioned symptoms persistently, please check with your doctor to rule out the possibility of kidney cancer

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of renal cell carcinoma, researchers examined the combined treatment with natural compounds and NVP-BEZ235 in human renal carcinoma Caki cells.

Where NVP-BEZ235 is an inhibitor of signaling pathways associated with the development of kidney tumors.

According to the tested analysis, curcumin markedly induced apoptosis in NVP-BEZ235-treated cells.

Co-treatment with curcumin and NVP-BEZ235 led to the down-regulation of Mcl-1 protein expression Involved in the regulation of apoptosis and survival of cancer cells but not mRNA expression in tested cells.

Furthermore, the co-administration also inhibited the protein associated with the anti-apoptotic activity of Bcl-2.

Interestingly, in colon cancer cell line analysis, Combined treatment with NVP-BEZ235 and curcumin reduced Bcl-2 expression in wild-type p53 HCT116 human colon carcinoma cells but not p53-null HCT116 cells.
In skin cell perspectively, NVP-BEZ235 combined with curcumin did not have a synergistic effect on normal human skin fibroblasts and normal human mesangial cells.
Based on the findings, researchers suggested that curcumin combined with the NVP-BEZ235 induced human renal carcinoma Caki cells apoptosis by regulating the protein associated with anti-apoptosis accompanied by blocking the activation of proliferative signaling pathways.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of kidney cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability by Seo BR1, Min KJ1, Cho IJ2, Kim SC2, Kwon TK. (PubMed)
(2) Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells by Li H1, Jin X, Zhang Z, Xing Y, Kong X. (PubMed)
(3) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton