By Kyle J. Norton
Hyperlipidemia is a condition associated with abnormally high levels of fat including cholesterol in the blood.
Most cases of hypercholesterolemia is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Hypercholesterolemia associated with forming plaques on the arterial wall that induces coronary artery disease (CAD), the leading cause of death in the US.
Sadly, 50% of people with hypercholesterolemia are not getting treatment.
Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that aging may have a strong impact on the increased incidence in the US.
Dr. Laura Trapani, the lead scientist wrote, “description of age-related disruption of lipid homeostasis, which particularly affects 3-hydroxy 3-methylglutaryl Coenzyme A reductase, the key rate-limiting enzyme”.
And, “gender-related dysregulation of this enzyme, providing new evidence for the different mechanisms driving dyslipidemia in elderly men and women. In addition, we introduce pharmacological methods of regulating HMGR and maintaining cholesterol homeostasis”.
With an aim to find a potential ingredient for the prevention and treatment of high blood cholesterol, researchers investigated the navy beans and rice bran efficacy in the regulation of serum cholesterol in hypercholesterolemic adults.
The study included children aged 8 to 13 years who are at risk for CVD due to abnormal lipids with total cholesterol ≥180 mg/dL and high-density lipoprotein (HDL) <60 mg/dL; low-density lipoprotein (LDL) ≥100 mg/dL and HDL <60 mg/dL; or non-HDL >100 mg/dL and HDL <60 mg/dL.
According to the tested assays received from 38 children who completed the trial (n = 9 control, n = 10 NBP, n = 9 RB, and n = 10 NBP + RB groups),
* Participants in the intervention groups showed a significantly increased intake of NBP and RB at week 4.
Dr. Borresen EC, the lead scientist, after taking other factors into account wrote, “Increasing NBP and/or RB intake is tolerable for children, and our findings suggest higher daily intakes are needed for a longer duration to induce favorable changes across multiple serum lipid parameters”.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) A Pilot Randomized Controlled Clinical Trial to Assess Tolerance and Efficacy of Navy Bean and Rice Bran Supplementation for Lowering Cholesterol in Children by Borresen EC1, Jenkins-Puccetti N2, Schmitz K1, Brown DG1, Pollack A2, Fairbanks A1, Wdowik M1, Rao S1, Nelson TL1, Luckasen G3, Ryan EP. (PubMed)
(2) Age-Related Hypercholesterolemia and HMG-CoA Reductase Dysregulation: Sex Does Matter (A Gender Perspective) by Laura Trapani and Valentina Pallottini. (Hindawi)