Not All Onions Process Antithrombotic and Thrombolytic Activity

By Kyle J. Norton

Antithrombotic activity is an action that reduces the formation of blood clots.
Antithrombotics are the medicines used therapeutically for prevention or treatment of dangerous coagulation, particularly in the acute thrombus.

Conventionally, medications that treat blood clots can be classified into anticoagulants and antiplatelet drugs
* Anticoagulants; The main function of anticoagulation is slow down clotting by reducing fibrin formation. However, they also used to prevent clots from forming and growing. 
* Antiplatelet agents; the main function of antiplatelet agents is to prevent platelets from clumping together. However, they also exert a similar effect to those of anticoagulation.

Thrombolytic activity is an action that dissolves dangerous clots in blood vessels, improves blood flow, with an aim to prevents damage to tissues associated with heart diseases and stroke.

Thrombolysis, also known as thrombolytic therapy, are types of conventional medicine that performs the thrombolytic activity.
Most common agents of thrombolytic therapy are Eminase (anistreplase), Retavase (reteplase), and Streptase (streptokinase, kabikinase).

There are many factors associated with the risk of blood clots including bone fractures, major surgery, use of birth control pills and pregnancy.

Epidemiologically, obesity, cigarette smoking, cancer, chemotherapy and personal history of abnormal blood clotting are also the prevalent factors found in the patients with thrombus.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the “king of vegetables” because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world’s cultures. 
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound which promotes blood thinning, researchers examined the effects of onion extracts antithrombotic effect.

According to the results of the experiment

* Toyohira, one of onion variety, showed significant antithrombotic activity both in vitro and in vivo.

* Moreover, Toyohira not only exhibited thrombolytic activity but also promoted antiplatelet effect.

* Superkitamomiji, 2935A, and K83211, other varieties of onion showed only thrombolytic activity.


* More interestingly, quercetin, the richest flavonoid in onion, showed no correlation in the antithrombotic activity.

Based on the results, researchers strongly suggested that onion A. cepa can be classified into varieties with or without antithrombotic and thrombolytic effects.
In other words, only certain varieties of onion process antithrombotic and thrombolytic activity.

Taken altogether, certain onion variety may be as antithrombotic and thrombolytic agents,  pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) An onion variety has natural antithrombotic effect as assessed by thrombosis/thrombolysis models in rodents by Yamada K1, Naemura A, Sawashita N, Noguchi Y, Yamamoto J. (PubMed)