By Kyle J. Norton
Cancer is a group of the medical disease characterized by cell growth irregularly in the organ tissue caused by DNA alternation.
Head and neck cancer (HNC) is a group of cancers located in the mouth, nose, throat, larynx, sinuses, or salivary glands.
The overall survival rate of 5 years after diagnosis is 62%.
Use of tobacco products and excessive alcohol consumption are considered the most prevalent factor associated with the increased risk of the disease.
In the urgency to find a potential compound for the treatment of head and neck cancers. researchers the anticancer activity of a novel oral agent, curcumin on FaDu and Cal27 cell lines.
According to the tested analysis, curcumin inhibited growth and induced apoptosis of the FaDu and Cal27 cell lines associated with the inhibition of the migration of head and neck cancers (HNSCC) and blocking the tumor angiogenetic activity.
Furthermore, curcumin also induced the cancer cell death by activating of the intrinsic apoptotic pathway (caspase-9) and extrinsic apoptotic pathway (caspase-8).
In vivo, injection of curcumin increased gene expression of SIRT1 in the regulation of cellular biological function in a xenograft mouse model.
In other words, by targeting the gene SIRT1 that promotes the survival of aging cells and increase cancer risk, curcumin not only can increase the chemo drug efficacy but also reduced the risk of side effects.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1 by Hu A1, Huang JJ2, Li RL3, Lu ZY3, Duan JL3, Xu WH1, Chen XP1, Fan JP. (PubMed)
(2) Synthetic curcumin analog UBS109 inhibits the growth of head and necksquamous cell carcinoma xenografts by Zhu S, Moore TW, Morii N, Howard RB, Culver D, Arrendale RF, Reddy P, Evers TJ, Zhang H, Sica G, Chen ZG, Sun A, Fu H, Khuri FR, Shin DM, Snyder JP, Shoji M. (PubMed)
(3) Epidemiological Trends of Head and Neck Cancer in the United States: A SEER Population Study by Moustafa Mourad, MD,* Thomas Jetmore, MD,† Ameya A. Jategaonkar, MD,‡ Sami Moubayed, MD,§ Erin Moshier, PhD,║ and Mark L. Urken, MD. (PMC)