Turmeric Decreases Pro-Inflammatory Cytokines in Immune Response

By Kyle J. Norton

Anti-inflammatory activity is the process to reduce inflammation or swelling without affecting the function of the immune system.

In the acute phase of infection, the immune first line of defense, the white blood cells, macrophages stimulates the production of blood platelet to cover the wound or cut and proinflammatory cytokines to destroy all invaders.

Most cases of acute infection are stopped at this phase and the wound is healed itself quickly.

However, if the wound is too large, then the recovery may take a longer period and through 4 overlap recovery stages. Any interruption in the overlapped recover stage may cause the formation of scars.

 Moreover, overproduction of proinflammatory cytokines that kills harmful pathogens may cause damage and death of nearby healthy cells, leading to the formation of scars, such as scar in the liver caused by hepatitis infection.

Additionally,  if the immune system can not destroy the invasive pathogens in a set of times, it will compromise, leading to low-grade inflammation. Prolonged low-grade inflammation caused by continuing the production of pro-inflammatory cytokines can result in serious and chronic diseases.

Diseases associated with chronic inflammation induced by protein, lipid and cellular damage include cardiovascular disease, diabetes, neurodegenerative disease,… and cancers.

The results have been found to cause cell death and alternation of cell DNA.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient which processes anti-inflammatory property researchers examined the effects of curcumin on inflammatory cytokines expression.

According to the tested differentiation, curcumin showed strong anti-inflammatory properties by suppressing the many pro-inflammatory cytokines and chemokines in a number of cell types and pathologic conditions.

Protein such as interleukin-18 (IL-18) associated with the generation of  Th1 in pro-inflammatory responses was also inhibited by the injection curcumin in vivo.

Furthermore, in E.coli LPS stimulated murine macrophage-like cells RAW264.7  induced the activation of pro-inflammatory cytokine IL-18 was also suppressed by curcumin in a concentration-dependent manner without inducing a cytotoxic effect on murine macrophage-like cells.

Based on the findings, researchers said, ” Our findings suggest that curcumin may be used as a potential therapeutic agent for the treatment of inflammatory diseases.

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of inflammatory diseases. pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin Suppresses the Production of Pro-inflammatory Cytokine Interleukin-18 in Lipopolysaccharide Stimulated Murine Macrophage-Like Cell by Renu Yadav, Babban Jee, and Sudhir Kumar Awasthi. (PMC)