Turmeric Protects the Cardiac Fibroblasts (CFs) of the Heart

By Kyle J. Norton

The heart formed part of the circulatory system pumps blood through the blood vessels. The blood provided not only nutrients to cell metabolism but also remove waste during the process.

Heart disease is a class of disease associated with blood vessels and the heart.

According to the statistics, heart disease is the leading cause of death for both men and women. Approximately, over 600,000 Americans die from heart disease each year or 1 in every 4 deaths are from heart disease.

A fibroblast associated with wound healing is a type of biological cell that produces collagen, and the structural framework (stroma) for body tissues.

Cardiac fibroblasts accompanied by myocytes, endothelial cells, and vascular smooth muscle cells are the permanent cellular constituents of the heart.
Cardiac fibroblasts play a critical role in the structure and function of the heart tissues involved in blood circulation to provide nutrients and fluids to the body daily functioning.

Under normal condition, cardiac fibroblasts are activated by the immune system following injury with the function to repair and remodeling tissues of the heart.

Activation of cardiac fibroblasts for heart tissue healing during the post-infarction has been found to involve several processes in the transition to the proliferative phase of infarct healing, including the stimulation of inflammatory reaction, followed by rapid suppression of proinflammatory cytokines and subsequent resolution of the leukocytic infiltrate.

Any disruption of the process may cause forming heart scars and reduce the function of the heart tissue to perform its normal function, leading to many cardiac pathologic conditions, including hypertensive heart disease and aortic stenosis.

Dr. Eva A Rog-Zielinska, the lead scientist, wrote, “Although myocardial infarction (MI) may be the most common cause of ventricular scarring in humans, scars also occur in non-ischaemic cardiomyopathies due to replacement fibrosis (see “Glossary”) during both pressure/volume overload [7] and normal ageing [8], although aging is not necessarily associated with fibrosis per se [9]”.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of myocardial infarction complications, researchers examined the efficacy of curcumin the role of curcumin on cardiac fibroblasts (CFs) after myocardial infarction (MI).

The study included MI induced by permanent ligation of the left anterior descending coronary artery in adult mice received curcumin for 4 weeks.

Based on the results of the tested analysis, curcumin significantly attenuated collagen deposition associated with overgrowth, hardening, and/or scarring of various tissues in vivo.


Cardiac fibroblasts (CFs) proliferation and migration and expression of the matrix (MMP) associated with inflammation induced by MI were inhibited by the infection of curcumin.

Furthermore, curcumin pretreatment also activated the expression of a gene which was inhibited by MI involved in the regulation of apoptosis, autophagy, DNA repair, inflammation



Researchers after taking other factors into account wrote, “Our results provide new insights into the mechanism underlying the anti-fibrotic effects of curcumin in the heart”.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiac fibroblasts (CFs) after MI, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro by Xiao J1, Sheng X1, Zhang X1, Guo M1, Ji X. (PubMed)
(2) The Living Scar – Cardiac Fibroblasts and the Injured Heart by Eva A Rog-Zielinska,1,2 Russell A Norris,3 Peter Kohl, and Roger Markwald. (PMC)