Whole Food Tomatoes, Kills Breast Cancer in Vitro

By Kyle J. Norton

Breast cancer is a medical condition caused by irregular cell growth in the breast tissue.

Breast cancer mostly starts in the cell on the surface of the inner lining of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the later stage, breast cancer can induce secondary metastasis through the circulation of blood and fluids.

Most cases of breast cancer are discovered by the women themselves or their partners.

According to the statistics, In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Today, due to the advanced technology and awareness of the disease, most cases of breast cancer in North American are diagnosed at an early stage.

The 5-year survival rate of breast cancer diagnosed in the local stage is close to 100%.

Most common symptoms at the early stage of breast cancer are lump (mass) in the breast, the armpit (lymph nodes), nipple discharge (clear or bloody), inverted or retracted nipple, scaly or pitted skin on nipple persistent tenderness of the breast and unusual breast pain or discomfort.

In the advanced stage, breast cancer may experience symptoms of bone pain (Secondary tumors in the bone), shortness of breath (Secondary tumors in the lung), unintentional weight loss and drop in appetite, (Secondary tumors in the liver) and headaches, neurological pain or weakness (Secondary tumors in the nervous system).

If you have some of the aforementioned symptoms, please make sure that you check with your doctor to rule out the possibility.

Out of many risk factors associated with breast cancer, some researchers suggested that the promotion of a high-fat diet in inducing the widespread obesity and overweight may have a strong implication on breast cancer.

Dr. Manuel Picon‐Ruiz, the lead scientist wrote, “Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)”.

And, “Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women and with worse disease outcome for women of all ages”.

In other words, if you are obese, your risk of breast cancer increases substantially compared to those who are not.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover a natural chemo remedy for the treatment of breast cancer, researchers examined the InsP 5-ptase fruit extract from tomato effect on breast cancer cells.

According to the Cellular assays, InsP 5-ptase fruit extract was more effective for reducing the proliferation of breast cancer cells compared to wild-type tomato fruit extract.

Breast cancer cells (MCF-7 line) exposed to an extract of transgenic fruits extract inhibited several genes compared to untreated cells or cells treated with wild-type tomato extract, according to the metabolome analysis of InsP 5-ptase.

Researchers after taking into account co and confounders wrote, “Together, this data demonstrates the potential role of the plant-derived metabolites in suppressing cell viability of cancer cells”.
In order to reveal more information about tomato anti-breast cancer property, researchers screened and elucidated the potential bioactive lycopene-derived products in breast-cancer and non-cancerous cells. 

According to the oxidation products separated from LYC-oxidation as fractions I-III, Fraction II showed higher cytotoxicity (IC50 value of 64.5 μM), cellular uptake, and apoptosis-inducing activity compared to fraction I and III in MCF-7 cells.

ROS exerted cytotoxicity of the fractions are generated by mitochondrial dysfunction in the tested cell line.
Dr. Arathi BPthe lead scientist wrote in the final report, “LYC-oxidation derivatives or metabolites are involved in growth inhibition of cancer cells. Exploration of specific oxidized-carotenoid products will give further insight into the field of nutritional biochemistry”.

Taken altogether, tomatoes processed a high amount of lycopene may be considered supplements for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Polyphenolic extract of InsP 5-ptase expressing tomato plants reduce the proliferation of MCF-7 breast cancer cells by Alimohammadi M1, Lahiani MH1, McGehee D1, Khodakovskaya M. (PubMed)
(2) Fractionation and Characterization of Lycopene-Oxidation Products by LC-MS/MS (ESI)+ by Elucidation of the Chemopreventative Potency of Oxidized Lycopene in Breast-Cancer Cell Lines by Arathi BP1, Raghavendra-Rao Sowmya P1, Kuriakose GC2, Shilpa S1, Shwetha HJ1, Kumar S3, Raju M4, Baskaran V5, Lakshminarayana R. (PubMed)
(3) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, PhD, 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, PhD. (PMC)